Take the bus number 1119 to the stop Nadraží Veleslavín. Switch to metro A and continue to the stop Malostranská, 4 stops. Get off there and go upstairs to take a tram. Take the tram number 22 in the direction of Nádraží Strašnice. Exit the tram at stop Národní Třída, 5th stop.
You are now leaving tram at the point marked by red „X“ sign. Follow the dotted line and go to Keyguru point – Hotel Koruna. It’s in the walking distance (3 minutes).
Public transport route from the airport google map